Publications
Our scientific publications underscore our best-in-class, proprietary chemistry and innovations in drug discovery and development.
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April 2023
Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference
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April 2022
Preclinical Evaluation of WVE-004, an Investigational Stereopure Antisense Oligonucleotide for the Treatment of C9orf72-associated ALS or FTD
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April 2022
Improvements to Hybridization-Ligation Enzyme-Linked Immunosorbent Assay Methods to Overcome Bioanalytical Challenges Posed by Novel Oligonucleotide Therapeutics
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April 2022
Development of a Sensitive Trial-ready Poly(GP) CSF Biomarker Assay for C9orf72-associated Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
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March 2022
Predicting Exon Criticality from Protein Sequence
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March 2022
Endogenous ADAR-mediated RNA Editing in Non-human Primates using Stereopure Chemically Modified Oligonucleotides
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February 2022
Impact of Guanidine-containing Backbone Linkages on Stereopure Antisense Oligonucleotides in the CNS
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January 2022
Control of Backbone Chemistry and Chirality Boost Oligonucleotide Splice Switching Activity
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February 2021
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models
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January 2021
Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species
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December 2020
Lessons from an Experiential Approach to Patient Community Engagement in Rare Disease
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September 2020
Investigational Assay for Haplotype Phasing of the Huntingtin Gene
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June 2020
Genotyping Single Nucleotide Polymorphisms for Allele-Selective Therapy in Huntington’s Disease
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September 2017
Control of Phosphorothioate Stereochemistry Substantially Increases the Efficacy of Antisense Oligonucleotides
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